KEGG   Homo sapiens (human): 5740
Entry
5740              CDS       T01001                                 
Symbol
PTGIS, CYP8, CYP8A1, PGIS, PTGI
Name
(RefSeq) prostaglandin I2 synthase
  KO
K01831  prostacyclin synthase [EC:5.3.99.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa01100  Metabolic pathways
Disease
H01633  High blood pressure
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    5740 (PTGIS)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    5740 (PTGIS)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.99  Other intramolecular oxidoreductases
    5.3.99.4  prostaglandin-I synthase
     5740 (PTGIS)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP8 family
   5740 (PTGIS)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 5740
NCBI-ProteinID: NP_000952
OMIM: 601699
HGNC: 9603
Ensembl: ENSG00000124212
UniProt: Q16647
Structure
Position
20:complement(49503874..49568137)
AA seq 500 aa
MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK
HGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDE
KARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTL
YGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKL
LSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL
KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE
VVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF
YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSR
YGFGLMQPEHDVPVRYRIRP
NT seq 1503 nt   +upstreamnt  +downstreamnt
atggcttgggccgcgctcctcggcctcctggccgcactgttgctgctgctgctactgagc
cgccgccgcacgcggcgacctggtgagcctcccctggacctgggcagcatcccctggttg
gggtatgccttggactttggaaaagatgctgccagcttcctcacgaggatgaaggagaag
cacggtgacatctttactatactggttgggggcaggtatgtcaccgttctcctggaccca
cactcctacgacgcggtggtgtgggagcctcgcaccaggctcgacttccatgcctatgcc
atcttcctcatggagaggatttttgatgtgcagcttccacattacagccccagtgatgaa
aaggccaggatgaaactgactcttctccacagagagctccaggcactcacagaagccatg
tataccaacctccatgcagtgctgttgggcgatgctacagaagcaggcagtggctggcac
gagatgggtctcctcgacttctcctacagcttcctgctcagagccggctacctgactctt
tacggaattgaggcgctgccacgcacccatgaaagccaggcccaggaccgcgtccactca
gctgatgtcttccacacctttcgccagctcgaccggctgctccccaaactggcccgtggc
tccctgtcagtgggggacaaggaccacatgtgcagtgtcaaaagtcgcctgtggaagctg
ctatccccagccaggctggccaggcgggcccaccggagcaaatggctggagagttacctg
ctgcacctggaggagatgggtgtgtcagaggagatgcaggcacgggccctggtgctgcag
ctgtgggccacacaggggaatatgggtcccgctgccttctggctcctgctcttccttctc
aagaatcctgaagccctggctgctgtccgcggagagctcgagagtatcctttggcaagcg
gagcagcctgtctcgcagacgaccactctcccacagaaggttctagacagcacacctgtg
cttgatagcgtgctgagtgagagcctcaggcttacagctgcccccttcatcacccgcgag
gttgtggtggacctggccatgcccatggcagacgggcgagaattcaacctgcgacgtggt
gaccgcctcctcctcttccccttcctgagcccccagagagacccagaaatctacacagac
ccagaggtatttaaatacaaccgattcctgaaccctgacggatcagagaagaaagacttt
tacaaggatgggaaacggctgaagaattacaacatgccctggggggcggggcacaatcac
tgcctggggaggagttatgcggtcaacagcatcaaacaatttgtgttccttgtgctggtg
cacttggacttggagctgatcaacgcagatgtggagatccctgagtttgacctcagcagg
tacggcttcggtctgatgcagccggaacacgacgtgcccgtccgctaccgcatccgccca
tga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (7)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (23)   
   RefSeq(nuc) (3)   
   GenBank (10)   
   EMBL (10)   
3D Structure (2)   
   PDB (2)   
Protein domain (1)   
   Pfam (1)   
All databases (51)   

Download RDF
DBGET integrated database retrieval system